![]() Half of cashew nut positive sera on dot blot were co- sensitised 19% to solely Anacardiaceae species and 31% to tree nuts, which indicated that cross-sensitisation/cross-reactivity is widespread among cashew nut allergic individuals. Profiling was specifically aimed at botanically related proteins of common tree nut species and other Anacardiaceae family members like pistachio, mango, pink peppercorn or sumac. In Chapter 3, we therefore aimed to determine the IgE cross-sensitisation and cross-reactivity profiles in cashew nut sensitised subjects. In addition, there is an urgent need for a consensus on key food allergy parameters to be applied in future food allergy research, to guarantee optimal lab- to-lab reproducibility and reliable use of predictive tests for protein risk assessment.Ĭashew nut allergic individuals may develop cross-reactive responses to foods that are phylogenetically related to cashew nut. Thus, there is still a strong need to better define the allergic reaction to predict the clinical outcomes of sensitization to novel food proteins. Findings indicated that, although the current available models are suitable for studying the pathophysiology of food allergy, they still couldn’t predict the magnitude of the allergic potential of a particular allergen. ![]() An overview is given of the best predictive risk assessment methods and endpoint parameters currently relied on in in vivo food allergy models with a focus on milk, egg and peanut allergens, addressing their strengths and limitations for assessing sensitization risks. Knowledge of newly identified cashew nut proteins provides a basis for further research to extend clinical diagnostic tests and treatments currently available for cashew nut allergy.Ĭhapter 2 includes an opinion on the use of current in vivo and ex vivo endpoints in murine food allergy models and their suitability for evaluating the sensitizing capacity of protein concentrates and/or food products. Using several different strategies, we evidenced that additional allergens must be present in cashew nuts, which presumably contribute to the elicitation of allergic symptoms in cashew nut allergic patients. Our knowledge of cashew nut proteins that can trigger an allergic reaction is currently very limited, especially compared to other nuts or seeds in which the allergen repertoire has been researched much more widely. ![]() In this thesis entitled ‘Cracking the cashew nut: strategies to identify and characterize novel allergens’, we aimed to apply innovative strategies and technologies to identify and characterize putative allergenic proteins in cashew nut, to broaden the current knowledge on cashew nut allergens beyond those already known (Ana o 1, Ana o 2 and Ana o 3). For clinical diagnosis of an allergy, it is essential to know the causative agents in the food product causing the allergic symptoms. Pediatricians should be aware of this emerging food allergy.Īnaphylaxis IgE-mediated allergy cashew nut sensitization tree nut allergy.Ĭopyright © 2021 Turkish Pediatric Association.Cashew nut allergy has been recognized as a severe tree nut allergy amongst (Dutch) children and young adults and its prevalence seems to be increasing. Early onset of moderate-to-severe atopic dermatitis and multiple food allergies are remarkable co-existing conditions in children who have been diagnosed with cashew nut allergy. During the follow-up, 90% of the patients who had cashew nut sensitization and co-existing food allergies to cow's milk and/or hen's egg developed tolerance to cow's milk and/or hen's egg, but none of the patients could tolerate cashew nut ingestion.Ĭashew nut is a potent allergen, causing severe allergic reactions that persist long term compared with other food allergies. Of the cashew nut-sensitized patients, 82.3% were diagnosed with moderate-to-severe atopic dermatitis, and all of them had multiple food allergies. All anaphylactic reactions were developed after the first consumption of cashew nuts. Overall, 29.4% of the patients presented with anaphylaxis. Skin symptoms were the most frequent clinical presentation, followed by gastrointestinal symptoms. Individuals sensitized to cashew nuts were examined.Ĭashew nut sensitization was detected in 17 (64.7% male mean age of symptom onset, 14 months) of 516 patients with food allergy. In this study, we aimed to evaluate the frequency of cashew nut sensitivity in a group of children with food allergy and the clinical features and course of cashew nut allergy.Ī retrospective chart review was performed on 516 children who presented with food allergy at a pediatric allergy department. Clinical reaction to cashew nuts may be severe, including anaphylaxis. The prevalence of cashew nut allergy is increasing.
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